Extended Data Fig. 4: Glioma subtype-specific aberrations in splicing factor expression lead to differential levels of NJ expression. | Nature

Extended Data Fig. 4: Glioma subtype-specific aberrations in splicing factor expression lead to differential levels of NJ expression.

From: Tumour-wide RNA splicing aberrations generate actionable public neoantigens

Extended Data Fig. 4

A. Ranked log2 fold change of genes within the top enriched pathways within GOBP when comparing IDHmut-A samples against IDHwt samples. B. Ranked log2 fold change of genes within the top enriched pathways within GOBP when comparing IDHmut-O samples against IDHwt samples. C-E. Heatmap demonstrating hierarchal clustering of splicing-related genes (rows) in GOBP mRNA Processing (C), GOBP RNA Splicing (D), and GOBP RNA Splicing via Transesterification Reactions (E) in TCGA samples (columns) ordered by the total number of expressed putative NJs. Further statistical details are found in Supplementary Table 3.

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