Extended Data Fig. 3: Nociceptive neurons in ganglia.
From: Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis
(a) Size distribution of tracer-positive neurons. (b) Representative images and quantification of CGRP+ neurons and IB4+ neurons in ganglia (n = 3 mice). Scale bar, 100 μm. (c) Representative images and quantification of CGRP+, SP+, SST+ neurons in ganglia (n = 3 mice). Scale bar, 100 μm. SP, Substance P. SST, Somatostatin. (d) Representative images and (e) quantification of neural tracing in NGF-overexpression mouse (n = 4 mice/group). Scale bar, 100 μm. (f) Quantification of molecular subtypes of the stomach-innervating sensory neurons in NGF-overexpression mouse (n = 4 mice/group). (g) Representative images of neural tracing in RTX-treated mice (n = 3 mice). Scale bar, 100 μm. (h) Relative expression of TrkA in sympathetic, parasympathetic and GC-traced sensory neurons (n = 5 mice). Data represent mean ± SEM, and P values were calculated by t test in e, by ANOVA in h. The statistical tests were two-sided.
