Extended Data Fig. 4: Protein-DNA interfaces.
From: Reconstitution of SPO11-dependent double-strand break formation
a,b, Details of predicted protein-DNA interfaces. Panel a shows Patch A (panels ii and iv) and Patch B (panels i and iii) from Fig. 3d. Panel b focuses on contacts close to the DNA bend, scissile phosphates and active sites. c, Correspondence between DNA-contacting residues predicted by the mouse SPO11 AlphaFold3 model and observed in S. cerevisiae Spo11 cryo-EM structures24.
