Fig. 4: Sex differences in POA maturation.
From: Sensory input, sex and function shape hypothalamic cell type development
a, Distance trajectories among inhibitory clusters from male (left) or female (right) mice. b, Distribution of distance to adult at each age, subtracting male from female distance, per cluster. P value indicates results from two-sided t-test, male versus female distances, across all cell types. n for increasing age: 124, 135, 132, 141, 140, 143 and 141 cell types examined over two independent experiments per sex. Boxplots show median, interquartile range and 1.5× interquartile range. P values for increasing age: 0.399, 0.0038, 0.0022, 0.0001, 6.9 × 10−8, 0.035 and 5.63 × 10−9. c, Fractional class distribution of cluster distance trajectories. d, At P65, sex differences in inhibitory clusters measured by the distance between male and female sample centroids in PCA space (normalized (norm.) to intra-sex distance) (left) or the number of sexDEGs detected (middle). Right, averaged gene expression of sex hormone receptors. e, Number of sexDEGs detected at a given age for all clusters that show significant sex differences.
