Extended Data Fig. 1: Directed evolution of an efficient and enantioselective SNAr enzyme. | Nature

Extended Data Fig. 1: Directed evolution of an efficient and enantioselective SNAr enzyme.

From: Engineered enzymes for enantioselective nucleophilic aromatic substitutions

Extended Data Fig. 1

Schematic showing the trajectory from SNAr1.0 to SNAr1.3. Mutations introduced are represented as CPK spheres at the Cβ. Three rounds of evolution afforded SNAr1.3, which contains six mutations. Library generation method, positions targeted, the number of clones evaluated, beneficial mutations and the most improved variant for each round are given in the table.

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