Extended Data Fig. 5: Validation of functional HARs and their target genes.
From: Comparative characterization of human accelerated regions in neurons
The WashU Comparative Epigenome Browser displaying regions with HARs and their orthologs. Quantitative effects of HAR on a, ARL8B, b, ONECUT2, and c, TBC1D5 expression. P values were calculated based on the two-sided two-sample t-test and adjusted by Benjamini-Hochberg multiple testing correction. The median, upper and lower quantiles are shown by circle and bar. Each dot represents one single cell. n is indicated in Supplementary Table 4d. The results of bulk CRISPRi followed by qPCR in human and chimpanzee neurons from three biological replicates are summarized on the right. P values were calculated based on the two-sided t-test.
