Extended Data Fig. 13: The tripartite pattern of interactions among extrusive-cohesin, cohesive-cohesin and condensin.
From: Extensive mutual influences of SMC complexes shape 3D genome folding
a, Schematic illustration showing two potential mechanisms (relocation model and eviction model) through which condensin disrupts extrusive-cohesin positioning. b, Schematic illustration showing the influence of extrusive-cohesin or cohesive-cohesin on mitotic chromosome structure. c, Schematic illustration showing the two potential models (passive model and reliance model) through which condensin disrupts cohesive-cohesin focal peaks. In the second model, condensin bypasses cohesive-cohesin. d, Schematic showing that cohesive-cohesin cannot be arrested at CTCF binding sites. e, Schematic showing the classic loop extrusion process without cohesive-cohesin. f, Schematic showing that extrusive-cohesin pushes cohesive-cohesin along one sister-chromatid without affecting the other chromatid. Cohesive-cohesin is positioned by extrusive-cohesin at CTCF binding sites.
