Extended Data Table 2 Summary of the mutations arising in in vitro resistance selection with SARS-CoV-2 B1, SARS-CoV-2 B1.617.2 (Delta) and SARS-CoV-2 B1.1.529 (Omicron)

From: A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein

  1. Nsp, nonstructural protein; 3CLpro, 3-chymotrypsin-like cysteine protease; RdRp, RNA-dependent RNA polymerase; endoRNAse, endoribonuclease; 2-ORM, 2’-O-ribose methyltransferase; E, envelope; M, membrane; N, nucleocapsid; ORF, open reading frame.
  2. Only mutations with a read frequency ≥15% are listed in the table. Identical mutations observed across different resistance virus samples are underlined.
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