Fig. 1: Discovery and characterization of mandimycin.
From: A polyene macrolide targeting phospholipids in the fungal cell membrane
a, BGC of mandimycin. b, Comparative high-performance liquid chromatography chromatograms of n-butanol extracts of wild-type (WT) S. netropsis DSM 40259 and the mandL-knockout mutant (left), accompanied by an agar diffusion assay of the extracts against C. albicans BNCC 186382 (right). (The locations of the added extracts are indicated by x symbols). c, The chemical structure of mandimycin determined by HR-ESI–MS, one-dimensional and two-dimensional NMR and bioinformatic prediction. PKS, polyketide synthase.
