Table 1 Antifungal activity of mandimycin against WHO priority fungal pathogens

Critical priority

Candida auris BNCC 357785

FCA^R, 5-FU^R, TBF^R

1

Candida auris BNCC 357784

FCA^R, 5-FU^R, TBF^R

1

Candida auris AMR05

Amp^R, FCA^R, 5-FU^R, TBF^R

2

Candida albicans BNCC 186382

FCA^R

0.25

Candida albicans BNCC 337321

FCA^R, 5-FU^R, TBF^R

0.5

Candida albicans BNCC 336485

FCA^R, 5-FU^R, TBF^R

0.5

Cryptococcus neoformans BNCC 225501

CPF^R, FCA^R, 5-FU^R

0.125

Cryptococcus neoformans BNCC 356067

CPF^R, FCA^R, 5-FU^R

0.125

Aspergillus fumigatus BNCC 122691

FCA^R, 5-FU^R, TBF^R

2

Aspergillus fumigatus BNCC 340016

FCA^R, 5-FU^R, TBF^R

2

High priority

Candida glabrata BNCC 337348

CPF^R, FCA^R, 5-FU^R, TBF^R

0.25

Candida tropicalis BNCC 340288

5-FU^R

0.5

Candida parapsilosis BNCC 337317

TBF^R, 5-FU^R

1

Mucor sp. BNCC 195604

FCA^R, 5-FU^R

0.25

Fusarium sp. BNCC 340967

CPF^R, FCA^R, 5-FU^R

1

Exophiala dermatitidis BNCC 360135

CPF^R, FCA^R, 5-FU^R

1

Medium priority

Candida krusei BNCC 185429

CPF^R, FCA^R, 5-FU^R, TBF^R

2

Cryptococcus gattii BNCC 354891

FCA^R, 5-FU^R,TBF^R

0.25

Talaromyces marneffei BNCC 334957

CPF^R, FCA^R, 5-FU^R

2

Emergomyces pasteurianus BNCC 362479

5-FU^R

2