Extended Data Fig. 5: Accumulation of signature-specific burdens.
From: The somatic mutation landscape of normal gastric epithelium
Burden of SNVs due to three signatures ubiquitous in gastric epithelium (a) SBS1, (b) SBS4/50 and (c) SBS18 versus age for gastric glands from non-cancer donors. Signature-specific burdens are also shown for gastric glands from all donors (excluding metaplastic glands) for (d) SBS1, (e) SBS5/40 and (f) SBS18. In all plots, the red dashed line indicates the maximum likelihood relation between age and SNV mutation burden due to a specific mutational signature obtained from a mixed effects model, with the grey box indicating a confidence interval. All P-values are obtained through a two-sided ANOVA test.
