Fig. 4: CNVs and recurrent trisomies.
From: The somatic mutation landscape of normal gastric epithelium
a, Overview of unique CNVs called across the WGS samples, split by the size of the event and further divided by specific site or chromosome. b, Heatmap of the number of microdissections with specific categories of structural variants (SVs) or CNVs per donor, along with donor cohort, age and number of WGS microdissections. c,d, Dot plots of the number of intrachromosomal structural variants (deletions, duplications or inversions) along phylogenetic trees of the gastric glands of two donors, PD40293 (c) and PD41767 (d), with recurrent gains of chromosome 13 or 20. Branch length represents the number of SNVs on each branch. The timing of the gain is indicated by the red (chr. 20), blue (chr. 13) or black (chr. 17q cnn-LOH) dot, with solid, coloured lines representing the 95% Poisson confidence interval around this estimate based on the number of duplicated and non-duplicated SNVs in regions affected by CNVs (numbers listed in Supplementary Table 4). Numbers indicate the parental allele that is gained. Asterisks denote microdissections from metaplastic glands. Del., deletion; dup., duplication; inv., inversion.
