Extended Data Fig. 4: Alveolar cells and fibroblasts strongly influence tissue-level cellular organization in fibrotic and resolving lungs.
From: Histological signatures map anti-fibrotic factors in mouse and human lungs
(A) Eigenvector centrality scores at PID 14 and 35, representing influence of individual cell types on tissue-level cellular organization. ATI cells, ATII cells, and fibroblasts constitute the highest-scoring nodes at both stages. (B-C) -Log10 normalized P values of differential fibroblast-alveolar cell interactions in fibrotic lungs (B) and differential fibroblast-alveolar cell interactions between fibrotic and post-fibrotic lungs (C). For panels B and C, p-values were calculated by an unpaired, two-tailed t-test.
