Extended Data Fig. 8: A two-binding site permeation model best captures voltage-dependent calcium block of AMPARs.
From: GluA2-containing AMPA receptors form a continuum of Ca2+-permeable channels
a. Schematic illustrations of the five Ca2+ binding models studied. b. The black dots are the calcium-dependent Gnorm values at −60 mV for each AMPAR (top to bottom). The colored lines are the fits for the five models (left to right). Gnorm is modelled as one minus the probability of calcium binding to site B2 (except model 1, where block is modelled based on calcium binding to site B1). Notice that all the models either overestimate block at low calcium concentration or underestimate block at high calcium concentrations, except for Model 4. c. Bayesian information criterion (BIC) computed for each model and AMPAR. Model 4 exhibited the lowest BIC across all AMPARs, indicating that the model is the best trade-off between high accuracy and low complexity.
