Extended Data Fig. 9: Nested model comparison identifies similarity in voltage sensitivity among AMPARs (see Supplementary Information).
From: GluA2-containing AMPA receptors form a continuum of Ca2+-permeable channels
a. Illustration of Model 4.0. The voltage dependences of both sites B1 and B2 are allowed to vary among all the AMPAR complexes. Model 4.0 is identical to Model 4. b. Illustration of Model 4.1. The voltage dependence of site B2 is allowed to vary among all the AMPAR complexes, but the voltage dependence of site B1 (\({\delta }_{1}\)) is identical among all AMPARs. c. Illustration of Model 4.2. The voltage dependence of site B2 (\({\delta }_{3}\)) of A1 + A2R607Eγ2 is allowed to vary, but the other AMPARs have identical voltage dependence. d. Illustration of Model 4.3. The voltage dependence of all AMPARs are identical. e. The number of unique parameters and the residual squared error (RSS) after fitting each of the nested models. f. Results of F-tests for model comparison. Models 4.0, 4.1, and 4.2 all performed significantly better than Model 4.3. However, Models 4.0, 4.1, and 4.2 achieved statistically indistinguishable (p > 0.05) fits to the data when taking the number of model parameters into account.
