Extended Data Fig. 7: Clustering of brain voxels by similarities of mitochondrial density and OxPhos activities.
From: A human brain map of mitochondrial respiratory capacity and diversity
a, Three visually defined UMAP clusters (upper) obtained after dimensionality reduction of mitochondrial features of all brain voxels (Fig. 2e) were used to predict whether voxels originated from GM, WM or a mixed sample (middle). The table lists prediction accuracy with the number of voxels identified as each type and the fractions that were identified correctly. Note that most localization errors occurred due to the presence of voxels with mixed composition, which complicates their anatomical mapping. Χ2(2, N = 1031) = 10.3, p < 0.01. b, Both MitoD and TRC values were higher in GM than the WM voxels (same data as on Fig. 2f; mean ± SD), but the TRC decreases more than MitoD. *** P < 0.0001 by 2-way ANOVA (F1,1260 = 18.67). c, Distribution of z-score values of each mitochondrial feature on the UMAP plot of GM voxels only (Fig. 2g).
