Extended Data Fig. 4: Volumetric transformation of mitochondrial parameters normalizes their distributions.
From: A human brain map of mitochondrial respiratory capacity and diversity
a, Distributions of complexes I, II and IV activities, CS activity and mtDNA density. Complex activities are averages from colorimetry and respirometry assays. b, Volumetric transformations of the data on a. Mitochondria density metrics and OxPhos complexes activities were calculated as averages of cube root and square root values from colorimetric and respirometry assays. c, Same data as b with voxels assigned to Gray matter (G, n = 339) and White matter (W, n = 169) clusters based on their anatomical location. Voxels with mixed identity (n = 194) are not shown for simplicity. d, Coefficient of variation (CV), skewness and Kolmogorov-Smirnov (K-S) distance of distributions of raw and transformed mitochondrial values from a-c.
