Fig. 1: The genetic architecture of osteoarthritis.
From: Translational genomics of osteoarthritis in 1,962,069 individuals
Meta-analysis-based odds ratios of the 962 index variants as a function of their risk-allele frequency, and phenotypic variance explained (VEP) for each variant indicated by the size of each circle. Each colour corresponds to an osteoarthritis phenotype: osteoarthritis at any site (ALLOA), hip osteoarthritis (HIP), knee osteoarthritis (KNEE), hip and/or knee osteoarthritis (HIPKNEE), spine osteoarthritis (SPINE), hand osteoarthritis (HAND), finger osteoarthritis (FINGER), thumb osteoarthritis (THUMB), total hip replacement (THR), total knee replacement (TKR) and total hip and/or knee replacement (total joint replacement, TJR).
