Fig. 2: Signal enrichment in cell types associated with skeletal development.
From: Translational genomics of osteoarthritis in 1,962,069 individuals
fGWAS enrichment for osteoarthritis in 30 cell states of the skeletal development atlas. Significance (FDR < 0.1) and effect size (log-transformed OR, log[OR]) are indicated by colour and dot size, respectively. InterzoneChon, interzone chondrocytes; PAX7high Chon, PAX7-expressing chondrocytes; ChondroPro1, chondrocyte progenitors; CyclingChon, chondrocytes with high cell cycle activity; ArticularChon1, articular chondrocytes with high TRPV4 and VEGFA expression; ArticularChon2, articular chondrocytes with high EPYC and low SOX9 expression; DLK1high Chon, DLK1-expressing chondrocytes; HypertrophicChon, hypertrophic chondrocytes; MaturingChon, maturing chondrocytes; LimbMes, early limb mesenchyme cells; Perichondrium, perichondrial osteoblast progenitors; MatureOsteocyte, osteocytes; FibroPRO1/2, fibroblast progenitors; SynFIB, synovial fibroblasts; DermFIB1/2, dermal fibroblasts; TENO, tenocytes; PAX7+ Myo, PAX7-expressing myocytes; MYH3+ Myo, MYH3 expressing myocytes; PERI, pericytes; PerineuralFIB, perineural fibroblasts; HIC1+ Mes, HIC1-expressing mesenchymal cells.
