Extended Data Fig. 11: Related to Fig. 4. Cruciform formation at MRE11 sites and characterisation of FANCM and SMARCAL1 binding sites.
From: Comprehensive interrogation of synthetic lethality in the DNA damage response
a, Profile plots and heat maps showing the intensity of cruciform signal at sites where MRE11 is enriched in the indicated cells. b, Consensus motif identified by performing MEME analysis on DNA sequences underlying cruciform peaks identified in SMARCAL1 KO:sgFANCM cells that do not overlap MRE11 sites. c, MEME analysis on DNA sequences underlying FANCM ChIP-Seq peaks in SMARCAL1 KO cells and SMARCAL1 peaks in FANCM KO cells. d, Venn diagram showing the overlap between ChIP-Seq peaks for SMARCAL1 and FANCM.
