Extended Data Fig. 6: BCR::ABL1 and CML in the All Of Us cohort.
From: Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia
a. CML diagnosis increases with BCR::ABL1 supporting read count. b. Each bar in the plot represents a BCR::ABL1 carrier identified, with the bar colour indicating the number of reads supporting their carrier status. Individuals diagnosed with CML or a pre-CML state during the follow-up period are marked with an asterisk. The Y-axis shows follow-up time, transformed using an arcsinh transformation (which approximates the natural logarithm while retaining zero-valued observations) for visualisation purposes. Exception received to the Data and Statistics Dissemination Policy from the All of Us Resource Access Board to display these data. c. CML incidence and BCR::ABL1 carrier status across age groups. In each panel, the bars represent the average number of new CML cases or BCR::ABL1 carriers per year, aligned with the left y-axis. The dots indicate the incidence rate per 100,000 population, corresponding to the right y-axis. For each age group, summary statistics were calculated by averaging annual statistics from 2018 to 2022, under the assumption that the population structure remained relatively stable during this period. WGS, whole genome sequencing subset of All of Us cohort.
