Fig. 2: Phylogenetic trees of chronic phase CML.
From: Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia
Each tree shows the pattern of sharing of somatic mutations in sampled colonies. The vertical axis on the right shows the somatic mutation burden at any point of the tree. Private branches represent those mutations present in only a single colony, and shared branches represent mutations present in one or more colonies. A branching point (coalescence) in the tree represents an ancestral haematopoietic stem cell that underwent a symmetrical self-renewing division wherein progeny of each of the daughter cells was sampled as a colony, and represents the MRCA of the downstream colonies, or the ‘clade’ that share this MRCA. The dots at the bottom represent individual sequenced colonies, with their colours corresponding to sampling time points. Highlighted branches are coloured by the driver mutation and copy number change that they carry.
