Extended Data Fig. 4: Molecular time phylogenetic trees with branch-specific C > T at CpG proportions.
From: Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia
Phylogenetic trees of 9 patients with proportions of mutational signatures annotated to their branches. Bar plots show the proportion of C > T at CpGs contributing to SNVs of different branch types. The Y-axis shows the somatic mutation burden since conception. The branches are categorised into four groups (i) branches of the BCR::ABL1-positive clonal expansion (“CML”), (ii) the ancestral branch of BCR::ABL1-colonies representing the lineage of origin of the CML (“pre-CML”), (iii) the earliest mutations within the CML (ie., the shared branches within the clonal expansion, “early CML”), and (iv) the branches of BCR::ABL1-negative colonies (wild-type, WT).
