Fig. 2: Specificity of TF–TF pairs.
From: DNA-guided transcription factor interactions extend human gene regulatory code
a, Close to half of all composite motifs are either specific within TF paralogue groups (orange) or subfamilies (grey). The remaining interactions are observed across broader structural families (blue). b, Specific composite motifs are formed between PITX and the FOXA/FOXD subfamily, and between HOXA2 and HOXB2 with the PROX subfamily. Alignment of individual motifs with composite motifs is shown. c, The indicated FOXK2–ELF1 composite motif detected by CAP-SELEX is enriched in overlapping ChIP–seq peaks for FOXK2 and ELF1. Red colour indicates enrichment of motif matches.
