Extended Data Fig. 2: Transcriptomic profile of NRXN1 RNA-binding proteins.
From: Phenotypic complexities of rare heterozygous neurexin-1 deletions
(a) Gene expression fold-change of select NRXN1 predicted RNA-binding proteins (RBP) across patients and control iGLUT neurons with statistical comparisons for STAR-Family RBPs, (n/d: Control = 6/2; 5′-Del = 6/2; 3′-Del = 6/2 | 1 batch), compared via two-tailed 1-way ANOVA, with Dunnett’s test (Sam68 F2, 15 = 15.36, 5′-Del p = 0.0001, 3′-Del p = 0.0181; Slm1 F2, 15 = 15.29, 5′-Del p = 0.0002, 3′-Del p = 0.0014; Slm2 F2, 15 = 20.22, 5′-Del p = 5.34E-05, 3′-Del p = 0.0003. (b) Gene expression fold-change of select NRXN1 predicted RNA-binding proteins (RBP) across patients and control iGABA neurons with statistical comparisons for STAR-Family RBPs, (n/d: Control = 5/2; 5′-Del = 6/2; 3′-Del = 6/2 | 1 batch), compared via two-tailed 1-way ANOVA, with Dunnett’s test (Sam68 F2, 14 = 1.449, 5′-Del p = 0.8826, 3′-Del p = 0.2172; Slm1 F2, 14 = 6.421, 5′-Del p = 0.0109, 3′-Del p = 0.0158; Slm2 F2, 14 = 21.06, 5′-Del p = 5.53E-05, 3′-Del p = 0.0002. n reported as samples/donors | independent batches.
