Fig. 4: Prediction 3: interareal connectivity.
a, iEEG DFC analysis of task-irrelevant trials revealed significant content-selective synchrony only for object-selective electrodes in V1/V2 (for example, top row; face-selective: npatients = 4 and nelectrodes = 30; object-selective: npatients= 4 and nelectrodes= 21), while showing significant content-selective synchrony for both categories in the PFC ROI (bottom row; face selective: npatients = 19 and nelectrodes = 81; object selective: npatients = 14 and nelectrodes = 57). Here and in panel b, significance was assessed using a cluster-based permutation analysis (P < 0.05, two-sided) and the colour bars represent the average change in the DFC between conditions. b, MEG DFC analysis of task-irrelevant trials (n = 65) revealed significant content-selective synchrony below 25 Hz for the face-selective GED filter in both V1/V2 (top left) and PFC (bottom left), but not for the object-selective GED filter (right panels). c, fMRI generalized psychophysiological interaction (gPPI; n = 70) on task-relevant and task-irrelevant trials combined revealed significant content-selective connectivity when FFA is used as the analysis seed. Various significant regions showing task-related connectivity with the FFA seed were observed including V1/V2, right intraparietal sulcus (IPS) and right inferior frontal gyrus (IFG). LH, left hemisphere; RH, right hemisphere. d, Analysis of iEEG face-selective DFC synchrony across tasks is shown at the single-electrode level in PFC (top) and V1/V2 (bottom) ROIs. Electrodes showing significant synchrony (tested using a permutation test, FDR-corrected, P < 0.05) in relevant (orange-red), irrelevant (purple) or combined relevant and irrelevant (black) trials are shown (averaged over 70–120 Hz and 0–0.5-s time window). DFC synchrony was observed in both tasks, but restricted to IFG for the GNWT analysis and V2 regions for the IIT analysis, consistent with the fMRI gPPI analysis shown in panel c. Brain surfaces in panels c,d are from Freesurfer.
