Extended Data Fig. 9: Cryo-EM structure determination of the BMAL1/HIF2A/DNA complex.
From: BMAL1–HIF2A heterodimer modulates circadian variations of myocardial injury
a, A cryo-EM micrograph of the BMAL1/HIF2A/DNA complex. b, Representative 2D class averages of the BMAL1/HIF2A/DNA complex. c, Flowchart of image processing of the BMAL1/HIF2A/DNA cryo-EM data. d, FSC curves of the BMAL1/HIF2A/DNA complex. The resolution for the BMAL1/HIF2A/DNA complex is 3.6 Å according to the gold-standard FSC = 0.143 criterion. e, Cryo-EM density map of the BMAL1/HIF2A/DNA complex coloured by local resolution. f, Angular distribution plot. g, Density map of the BMAL1/HIF2A/DNA complex generated by deepEMhancer. h, Histogram and directional FSC plot generated by 3DFSC indicates that 90% of directions achieve a resolution better than 4 Å. i and j, Local structures with their corresponding densities are shown.
