Correction to: Nature https://doi.org/10.1038/s41586-024-08300-4 Published online 8 January 2025

In the version of the article initially published, two simulation studies that modelled the effect of germline gene editing on human disease were omitted and have now been added as refs. 20 and 21: Oliynyk, R. T. Quantifying the potential for future gene therapy to lower lifetime risk of polygenic late-onset diseases. Int. J. Mol. Sci. https://doi.org/10.3390/ijms20133352 (2019) and Oliynyk, R. T. Future preventive gene therapy of polygenic diseases from a population genetics perspective. Int. J. Mol. Sci. https://doi.org/10.3390/ijms20205013 (2019). The authors regret this omission and have added a sentence to the main text and a paragraph in the revised Supplementary Note 1.