Extended Data Fig. 8: Signature of natural selection in the FLG gene region.
From: Genome diversity and signatures of natural selection in mainland Southeast Asia
a, The regional plot of CMS scores and recombination rates in the FLG region, in which the peaks indicate the selective signals. The peak SNVs are marked with colors. The bottom panel shows the LD blocks of the 262 PS-SNVs with MSEA-enriched alleles. The dot size denotes to the P-value of the CMS score, and statistical significance was assessed using chi-squared (χ2) test. The calculated recombination rates (r2) indicate the estimated linkage disequilibrium (LD) degree between the peak SNV and the other SNVs and are coded in colors. b, The TCS network of the FLG region showing a MSEA-specific haplogroup. Each node represents a haplotype, and the size is proportional to its frequency. The MSEA-specific haplogroup is highlighted.
