Extended Data Fig. 7: Response of TS and VS dopamine responses to value manipulations.
From: Dopaminergic action prediction errors serve as a value-free teaching signal
a, Schematic of the outcome manipulation task design. b, Modelled responses for how APE and RPE signals would respond to changes in reward outcome. c, Example TS response to omissions, normal sized and large rewards. d, Group data (n = 6 mice) for TS dopamine response size to omission, normal and large reward (p = 0.84, p = 0.54, paired two-sided t-test, adjusted using Bonferroni correction), (Cohen’s d: large > normal 0.40, normal > omission 0.57). e, Same as c but for a VS recording. f, Same as d but for VS recording (n = 7 mice, p = 3.16×10-6, p = 8.87×10-6, paired two-sided t-test, adjusted using Bonferroni correction), (Cohen’s d: large > normal 7.01, normal > omission 5.89). g, Schematic of the predicted value manipulation task design. h, Model predictions for changes in predicted outcome value. i, Example movement-aligned TS response when the relative value of the cues changed. j, Summary data showing the change in movement-aligned response in the TS for relative value changes (p = 0.26, paired two-sided t-test) (n = 5 mice), Cohen’s d = 0.58. k, Same as i but for the VS response aligned to cue. l, Same as j but for the VS response aligned to cue (p = 2.41×10-4, paired two-sided t-test) (n = 5 mice), Cohen’s d = 5.56. All error bars represent SEM.
