Fig. 2: TS dopamine release is correlated with contralateral movement.
From: Dopaminergic action prediction errors serve as a value-free teaching signal
a, Schematic of the experimental approach for recording dopamine activity in the VS and TS. The anterior–posterior distance between the VS and TS are not to scale. b, Fluorescent images showing optical fibre locations and dLight expression in the TS and the VS. Scale bar, 1 mm. c, Recording fibre locations from the VS and TS matched to the reference atlas. d, Example of a TS and a VS recording session aligned to time of leaving the centre port to make a contralateral (contra) choice or an ipsilateral (ipsi) choice. White dot shows time of entering contralateral or ipsilateral choice port. e, Average photometry traces in TS (n = 10 mice) and VS (n = 7 mice) aligned to task events. Shaded time windows show significant differences between the two trace types in each subplot, calculated by performing two-sample t-tests on 0.1-s bins and a P value threshold for significance of 0.01. f, Average response kernels to behavioural events for recordings in the TS and VS. Shaded time windows are calculated as in e. Coeff., coefficient. g, Percentage explained variance (var.) of the whole recording session (VS median = 31.3; TS median = 5.50) and for different behavioural kernels for linear regression models fitted on VS (n = 7 mice) and TS (n = 10 mice) recordings. Error bars represent s.e.m. in e,f. In box plots, boxes represent quartiles 2 and 3, the centre line shows the median and whiskers extend to the furthest data point within 1.5 times the inter-quartile range from the box.
