Extended Data Fig. 2: Histology and quantification of TS lesions.
From: Dopaminergic action prediction errors serve as a value-free teaching signal
a, Representative image of a lesioned brain illustrating the image analysis used to quantify the proportion of lesioned striatum. Slices were registered to the atlas and the area with remaining neurons (as stained by NeuN) was defined. The rest of the striatum was considered as lesioned. b, Quantification of the lesion area for the 11 mice in the caspase dataset, across several coronal slices of the posterior striatum, that include the entire TS. c, Learning rate (performance vs. trial number) of individual mice in the lesion in TS and the control groups. Light blue and light gray traces are from mice that had an initial bias. d, Differences of means in performance between control and lesion groups. Dotted lines indicate the 95% confidence interval for the shuffled data (see methods). e, Learning rate for trials with the low tone stimulus (performance vs. trial number) of lesion TS and the control groups (shaded area indicates standard deviation). f, Same as F but for high tone stimulus trials (shaded area indicates standard deviation).
