Extended Data Fig. 6: Impact of TAUT loss on leukaemia development in murine models.
From: Taurine from tumour niche drives glycolysis to promote leukaemogenesis
a, Number of live LSCs (left) and their CFU (right) post co-culture with leukaemic MSCs transduced with shCdo1 or shLacZ (mean ± s.e.m.; n = 6 independent culture wells; data combined from 2 independent experiments; one-way ANOVA). b, Survival curve shows the impact of taurine supplements on murine leukaemia progression in irradiated recipients (n = 10 per cohort; data combined from two independent experiments; log-rank test). c, Representative FACS plots and quantification of BM engraftment in cancer at initiation and end point (mean ± s.e.m.; n = 3 +/+ and n = 5 −/−; data combined from two independent experiments). d-g, Graph (d) shows number of microenvironmental cells per mouse leg. Representative FACS plots and quantification of MSC (e), osteolineage (f), and endothelial (g) frequency (left) and total cell number (right) at initiation and end point (mean ± s.e.m.; n = 3 +/+ and n = 5 −/−; data combined from two independent experiments). h, Representative FACS histogram and quantification of Lin+ frequency in bcCML BM (mean ± s.e.m.; n = 14 animals per cohort; data combined from three independent experiments; c, e-h unpaired two-tailed Student’s t-test).
