Extended Data Fig. 9: Representative microbiome and genomic profiles of colibactin-exposed samples.

a-d, Microbiome and genomic profiles of representative samples corresponding to the four different sample types according to colibactin exposure: genomic+ and pks + (a), genomic+ and pks− (b), genomic- and pks + (c), and genomic- and pks−. The genomic status is defined by the presence of SBS88 or ID18 signatures, while the microbiome status (pks) is determined by the coverage of at least half of the pks island, and suggests ongoing and/or active pks+ bacterial infection. Circos plots display Reads Per Kilobase of transcript per Million (RPKM) values across clb genes within the pks island (left). Bar plots represent the proportion of mutations attributed to SBS88 and ID18 colibactin signatures compared to others (center), and are displayed next to mutational profiles of single base substitutions (SBS-288 mutational context) and small insertions and deletions (ID-83 mutational context) for each sample (right).