Extended Data Fig. 10: Driver mutations associated with colibactin mutagenesis in early-onset and late-onset colibactin positive cases and with country-enriched mutational signatures in microsatellite stable colorectal cancers.

a-b, Bar plots indicating the proportion and number of driver mutations probabilistically assigned to colibactin-induced and other mutational signatures, including single base substitutions (a) and small insertions and deletions (indels; b), with samples separated by age of diagnosis in early-onset (under 50 years of age; left) and late-onset (50 or over; right). Driver mutations were divided into different groups, including the APC c.835−8 A > G splicing-associated driver mutation, other APC driver mutations, TP53 driver mutations, and driver mutations affecting other cancer driver genes. c-d, Bar plots indicating the proportion and number of mutations in chromatin modifier genes probabilistically assigned to colibactin-induced and other mutational signatures, including single base substitutions (c) and indels (d), in the 169 colibactin positive cases. e-g, Bar plots indicating the proportion and number of driver single base substitutions (e and f) and indels (g) in cancer driver genes probabilistically assigned to specific mutational signatures in cases from Colombia (e) or Argentina (f and g) compared to other countries.