Extended Data Fig. 7: Associations between CM activity and tissue, sex, and age group.
From: Cross-tissue multicellular coordination and its rewiring in cancer
(a) Bar plot showing the proportion of variance explained of CM activities by tissues, measured as adjusted R2 from linear models. Significance of linear models is indicated. (b) Heat map showing associations of CM activity with sexes in non-reproductive tissues. Two-tailed unpaired Wilcoxon tests. (c) Heat map showing associations of CM activity with age groups. Kruskal–Wallis tests. (d) CM09 activity and frequencies of its subsets in individual thymus samples stratified by age groups. Two-tailed unpaired Wilcoxon tests. (e) Bar plot showing associations between age groups and frequencies of immune cell subsets in the spleen. Kruskal–Wallis tests. (f) Frequencies of selected immune subsets in individual spleen samples stratified by age groups. Two-tailed unpaired Wilcoxon tests. (g) Frequencies of the B08 subset in individual spleen samples stratified by age groups. Two-tailed unpaired Wilcoxon tests. For box plots in d,f,g, the center line represents the median, the box limits delineate the upper and lower quartiles, and the whiskers extend to the highest and lowest values within 1.5× the interquartile range.
