Fig. 3: Methods, assays and questions.

Overview of sampling methods and sequencing assays deployed in the SMaHT Network, as well as the biological questions, outcomes and inferred mutational patterns from downstream analyses of the catalogue of somatic mutations across normal tissues, including mutation rates or burdens, selection, lineage tracing and mutational signatures (reference signatures were obtained from https://cancer.sanger.ac.uk/signatures)⁴⁴. ZMW, zero-mode waveguide.