Extended Data Fig. 8: Characterization of thymic cellularity stratified according to total transcriptome of purified TECs.
From: Developmental trajectory and evolutionary origin of thymic mimetic cells
a, Percentage of indicated haematopoietic cell types among thymocytes in non-transgenic control mice (FVB) and two groups of transgenic Foxn1:Foxn1Δ3ex2; Foxn1−/− mice assigned to the collapse and recovery phases. n as indicated in the panels, each data point shows one thymus explant from one animal. p values between groups were derived from pairwise two-sided t tests with Bonferroni correction after significant (p < 0.05) ANOVA result. Boxplots encapsulate the first to third quartile, a line indicates the median. Whiskers extend to the furthest point with a distance of up to 1.5 times the interquartile range from the boxes. b, Visualization of expression changes between Foxn1:Foxn1Δ3ex2; Foxn1−/− mice and non-transgenic wildtype mice stratified into collapse (left panel) and recovery phases (right panels). Each line represents a gene of the indicated signature and its position on the x axis shows the value of the t statistic derived from differential expression analysis. Numeric values listed in the left column represent log10(adj. p) from enrichment analysis with camera25. Log transformed p values of upregulated sets were multiplied with −1 so that positive values indicate upwards directionality, and negative values indicate downwards directionality, respectively.
