Extended Data Fig. 9: Additional examples of multi-tissue responses to mutations.
From: In vivo mapping of mutagenesis sensitivity of human enhancers
(A) Illustration of paired block mutagenesis outcomes for all possible combinations of loss and gain mutations. Bars represent ranges of possible outcomes that would be classified as cumulative or non-cumulative. Redundant is a special case of non-cumulative in which combined mutagenesis of two blocks resulted in an outcome exactly as severe as the most severe of individual block outcomes. (B) Additional cumulative pair examples. (C) Remaining three non-cumulative pairs. White arrowheads indicate loss of function. Black arrowhead indicates gain of function.
