Extended Data Fig. 4: Influence of passive smoking on the landscape of ID, DBS, CN and SV signatures in LCINS.
From: The mutagenic forces shaping the genomes of lung cancer in never smokers
a–e, Differences in DBS, ID, CN, and SV burden using univariate comparisons based on two-sided Wilcoxon rank sum tests (a) as well as multivariable linear regressions considering clinical and epidemiological covariates (b–e), including age, sex, genetic ancestry, and tumour purity (n = 250 passive smokers, n = 208 non-passive smokers). The line within the box indicates the median, the upper and lower ends indicate the 25th and 75th percentiles, whiskers show 1.5 × interquartile range, and values outside are shown as individual data points (a). Error bars indicate 95% CIs (b–e). f, Enrichment of mutational signatures derived from DBS, ID, CN, and SV alterations. Horizontal lines marking statistically significant thresholds were included at 0.05 (dashed orange line) and 0.01 FDR value levels (dashed red line). Statistical significance was evaluated using multivariable logistic regression models for passive smoking history and adjusted by age, sex, genetic ancestry, histology and tumour purity.
