Extended Data Fig. 5: Submucosal and myenteric responses to luminal glucose are partly mediated by SGLT1.
From: Nutrients activate distinct patterns of small-intestinal enteric neurons
a,b, Repeated mucosal glucose (300 mM) application, separated by 10 min Krebs perfusion, evoked reproducible responses in the (a) SMP (n = 6 FOVs imaged) and (b) MP (n = 6 FOVs imaged) under control conditions. a’, Submucosal (n = 6 preparations) and b’, myenteric (n = 6 preparations) responses to mucosal glucose perfusion were significantly inhibited by mizagliflozin (selective SGLT1 inhibitor, 1 µM; two-sided paired t-test). Drawing in a is adapted from ref. 30 (Wiley).
