Extended Data Fig. 6: Polymorphic Human Endogenous Retrovirus Type K (HERV-K) insertions annotated using SVAN.
From: Structural variation in 1,019 diverse humans based on long-read sequencing
a, c) Length distributions of HERV-K and solo long terminal repeat (solo-LTR) insertions. b, d) Number of instance specific repetitive DNA element classes overlap the breakpoints for HERV-K and solo-LTR insertions. e) Alignments of HERV-K (top) and solo-LTR (bottom) insertions to the HERV-K113 provirus reference, visualized using the Integrative Genomics Viewer (IGV). Insertion coordinates relative to the CHM13 reference genome, and cytoband identifiers from previously reported39 insertions. A schematic in the bottom right illustrates the two possible configurations for a full-length HERV-K insertion, with or without an LTR-flanking repeat present in the reference genome.
