Extended Data Fig. 5: Meal pattern analysis in PyyCre_Tlr5^fl/fl mice.

(a) Schematic of meal pattern analysis showing that meals are defined as consumption >0.1 g with at least 10 min in between bouts. Cumulative food consumption was assessed for PyyCre_Tlr5^fl/fl and _Tlr5^fl/fl littermate control mice across 3 days in the TSE Phenomaster for (b) male and (c) female mice. Quantification of meals across 72 h in the dark and light cycles in males and females of (d) meal duration, (e) meal size, and (f) inter-meal interval. Box plots represent interquartile range, white lines indicate median. and (g) meal count (PyyCre_Tlr5^fl/fl: n = 9 male mice and n = 9 female mice; _Tlr5^fl/fl: n = 6 male mice and n = 8 female mice; *P < 0.05 genotype main effect by ANOVA with post-hoc two-tailed Tukey HSD).