Fig. 5: MUSAS for kinetic biosensing and drug delivery.
From: Mechanical underwater adhesive devices for soft substrates
a, (i) Kinetic biosensing via ultraminiaturized, battery-free, wireless MUSAS radiofrequency identification (RFID) temperature sensor on a tilapia model. Scale bars, 1.5 cm (left), 200 µm (right). (ii) Demonstration of MUSAS adhesion to various location of tilapias. Scale bar, 1 cm. Also see Supplementary Video 8. (iii) Retention time of MUSAS on swimming tilapias. n = 3 tilapias per body location. (iv) In vivo kinetic temperature sensing of MUSAS on a swimming tilapia. Scale bar, 2 cm. Also see Supplementary Video 9. RSSI, received signal strength indicator. b, (i) Digital health monitoring of GERD with MUSAS-based impedance sensor. Scale bars, 5 mm (left), 1 mm (right). (ii) MUSAS detecting gastric reflux in a swine gastric fluid reflux model. c, (i) MUSAS-enabled sustained drug delivery of HIV PrEP CAB. Scale bar, 1 cm. (ii) In vitro release kinetics of CAB via different sustained-release matrices. n = 3 samples. The error bars represent mean ± s.d. (iii) Plasma pharmacokinetics of sustained CAB release through a 7-day study on a swine model. n = 3 Yorkshire pigs per treatment. The error bars represent mean ± s.e.m. d, (i) Luciferase mRNA delivered via MUSAS. Scale bar, 5 mm (left), 1 cm (right). (ii) In vivo imaging system detecting luminescent signal of luciferin conjugating proteins expressed through functionally transfected luciferase mRNA. Colour bars denote radiance measurements. Scale bar, 1 cm. (iii) Fluorescent immunohistochemistry to evaluate transfection of luciferase mRNA in the buccal and pharyngeal regions of a swine model. Scale bar, 400 µm. n = 3 Yorkshire pigs per treatment. Also see Extended Data Fig. 9.
