Extended Data Fig. 8: Mitochondrial OXPHOS pathway changes across T-cells following IAV infection with or without DCCs or CD4 depletion.
From: Respiratory viral infections awaken metastatic breast cancer cells in lungs
The top-left heatmap illustrates statistically significant changes in custom mitochondrial OXPHOS pathways, ranked by normalized enrichment score (NES) and determined through fGSEA analysis. Only pathways with a false discovery rate (FDR) < 0.25 are displayed. The remaining heatmaps depict individual log2(Fold-Change) values for mitochondrial OXPHOS complex genes, comparing the experimental groups: Her2+IAV vs. HER2 + PBS, Her2+IAV vs. WT + IAV, and Her2+IAV+anti-CD4 vs. Her2+IAV. All genes are displayed, with statistical significance indicated by * for adjusted p-value < 0.05 and # for raw p-value < 0.05. For groups with depletion of CD4+ cells using anti-CD4 antibody, the residual cells in CD4+ effector, CD4+ memory and regulatory T-cell clusters exhibited minimal detection of CD4, and thus are not analyzed.
