Extended Data Fig. 2: Inflammatory and EMT gene expression changes in DCCs 9 dpi and IL-6 and IL-1β concentration post IAV infection.
From: Respiratory viral infections awaken metastatic breast cancer cells in lungs
Heatmaps of genes for Interferon Alpha Response (a), Interferon Gamma Response (b), IL6/JAK/STAT3 Signaling (c), and Epithelial Mesenchymal Transition (d) pathways from RNA-seq for DCC comparing PBS to IAV at 9 dpi. Concentrations of IL-6 and IL-1β in BAL from MMTV-Her2 mice treated with PBS or infected with IAV at 3, 6, 9, 15 dpi (e, f). Concentration of IL-6 in supernatant of mouse tracheal epithelial cells (MTECs) treated with PBS or 24 h post IAV infection (g) (n = 3/group). Significance is determined by two tailed Student’s t test. All box-and-whisker plots are presented as maximum value (top line), median value (middle line), minimum value (bottom line) with all data points shown (dots).
