Extended Data Fig. 4: Lithium deficiency and Wnt/β-catenin signaling.
From: Lithium deficiency and the onset of Alzheimer’s disease
a, Pathways associated with Li deficiency in WT microglia. Wnt/β-catenin/TCF signaling is among the most significantly enriched signaling pathways and is predicted to be inhibited (predicted activation and inhibition are depicted as orange and blue, respectively). b,c, Functional network diagrams of Wnt/β-catenin/TCF signaling in Li-deficient WT and 3xTg microglia (b), and in excitatory neurons (c, left panel) and oligodendrocytes (c, right panel) from Li-deficient 3xTg mice. In each network, associated DEGs (FDR < 0.05) are highlighted in red (upregulated) or green (downregulated). In a, color intensity reflects z-score strength. Analysis was performed using the Ingenuity Pathway Analysis (IPA) platform. False discovery rate (FDR) was determined using a one-sided Fisher’s exact test followed by Benjamini-Hochberg correction for multiple comparisons.
