Extended Data Fig. 13: IGF1R inhibition prevents iMG-induced promotion of MGE proliferation.
From: Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1
a, Experimental schematic diagram showing that MGEOs transplanted with or without iMG were treated with PBS or IGF1R inhibitors -GSK4529 and Picropodophyllin- for two days at week 6. BrdU was administered during the last four hours to label proliferating cells. b-c, IHC images and bar graphs showing that GSK4529 and Picropodophyllin prevented iMG-induced promotion of MGE proliferation. N = 9, 9, 8; 10,10, 8; two-way ANOVA and post-hoc Bonferroni’s test for selected comparisons. Data in (c) were shown as means ± SEM. Illustration in a was created using BioRender (https://biorender.com).
