Fig. 6: CCD predicts poor patient survival.
From: Clone copy number diversity is linked to survival in lung cancer
a, CCD comparison (two-sided Wilcoxon) between tumours of patients with (n = 117 tumours) and without (n = 126 tumours, 3-yr follow-up period6) metastatic disease. b, CCD comparison between tumours with only subclonal (n = 73 tumours) or truncal (n = 44 tumours) seeding. c,d, Kaplan–Meier curves showing difference in DFS between patients with tumours with greater or less than the median value of CCD (median CCD = 21.95; c) and with high, mid or low tertile values of CCD (d). The number of patients at risk in each group is indicated below each time point. CI, confidence interval. e, A multivariable Cox proportional hazards model including covariates age, stage, pack-years, histology, sex, adjuvant treatment status, CCD (increase per standard deviation) and fraction of the aberrant genome with subclonal SCNAs (SCNA-ITH (sample), increase per standard deviation). The measure of centre represents the hazard ratio estimate and its 95% confidence intervals are indicated in parentheses and represented by the error bars. All survival analyses were performed on n = 387 patients. pTNM, pathological tumour–node–metastasis; AIC, Akaike information criterion. *P < 0.05; **P < 0.01; ***P < 0.001. In data represented using box plots, the box represents the interquartile range (IQR) with the median line. Whiskers denote the lowest and highest values within 1.5 times the IQR from the first and third quartiles, respectively.
