Extended Data Fig. 1: ALPACA assumptions.
From: Clone copy number diversity is linked to survival in lung cancer
a-c, Variation of clustering consistency with varied SNV and CNA mutation rates, (a) assuming neutral growth, (b) with selection on CNAs only, (c) and with selection on both CNAs and SNVs. For all pairs of mutation rates, consistency values are averaged across 10 simulations. d, Clustering concordance of mutations from TRACERx primary cohort cases between the full set of mutations and subsets. Each box plot represents one subset (n = 310), where 5%, 15%, 25%, or 50% of the genome with extensive SCNA has been removed.
